Evidence map›Paper›PMID 42004401›Full record

ArticleFerroptosis and oxidative stress2026

Ferroptosis surveillance: Insights from

Alec J Vaughan, Mario Palma, Jessalyn M Ubellacker, Thales Papagiannakopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ferroptosis and oxidative stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alec J VaughanDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Mario PalmaDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Jessalyn M UbellackerDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Thales PapagiannakopoulosDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.

Funding

Identifying metabolic dependencies in genetic subtypes of KRAS-driven lung cancerR37CA222504 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAPAGIANNAKOPOULOS, THALES · 2018 to 2024
$3.3M
Training Program in Cell BiologyT32GM136542 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMITH, SUSAN · 2020 to 2024
$3.0M
Novel approaches to target KEAP1 mutant tumorsR01CA283049 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Thales Papagiannakopoulos · 2024 to 2026
$2.0M
Investigating the therapeutic potential of a novel glutamine antagonist in KEAP1 mutant lung cancerR01CA262562 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Thales Papagiannakopoulos · 2024 to 2026
$2.0M
Uncovering Genotype Specific Vulnerabilities in KRAS Mutant Lung Cancer?R01CA227649 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAPAGIANNAKOPOULOS, THALES · 2018 to 2022
$1.9M
Preventing Melanoma Metastasis by Targeting Lipid Vulnerabilities in LymphR01CA282202 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Jessalyn Ubellacker · 2024 to 2026
$1.3M
NCI NIH HHS R01 CA227649NCI NIH HHS R01 CA262562NCI NIH HHS R01 CA282202NCI NIH HHS R01 CA283049NCI NIH HHS R37 CA222504NIGMS NIH HHS T32 GM136542
6 · The paper itself

Abstract

Ferroptosis has emerged over the past decade as a compelling therapeutic avenue for cancer, prompting intense interest in strategies that selectively induce or inhibit this form of cell death. Although substantial progress has been made in identifying genes that regulate ferroptosis sensitivity and in developing small-molecule modulators, it remains unclear which molecular targets offer the greatest therapeutic potential in specific tissues and contexts. Here, we highlight fundamental differences between

Indexed as

FerroptosisGPX4–FSP1 axisin vivo modelingmicroenvironment

Identifiers

PMID42004401
PMCPMC13089937

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.