Discrepancies in loneliness and social isolation predict cognitive impairment through chronic disease burden.

Dakota W Cintron, Tomiko Yoneda, Hebi Wang, Eileen K Graham, Anthony D Ong

Abstract read

In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Life Sustaining Well-Being Practices and Physiological Health Among Black Men.Journal of racial and ethnic health disparities · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dakota W CintronDepartment of Psychology, Claremont Graduate University, USA.

Tomiko YonedaDepartment of Psychology, University of California, Davis, USA.

Hebi WangDepartment of Statistics, University of California, Davis, USA.

Eileen K GrahamDepartment of Medical Social Science, Northwestern University, USA.

Anthony D OngDepartment of Psychology, Cornell University, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The discrepancy between loneliness and objective social isolation (social asymmetry) has been linked to poorer cognitive aging, yet the biobehavioral pathways underlying this association remain unclear. This study tested whether chronic disease burden or allostatic load mediated associations between social asymmetry and subsequent cognitive performance. Methods: We analyzed data from 840 adults (mean age = 54 years, range = 34-81 years) from the Midlife in the United States (MIDUS) Biomarker Project using structural equation modeling to test parallel mediation through allostatic load and chronic disease burden. Results: Social asymmetry was associated with greater chronic disease burden but showed minimal association with allostatic load. Chronic disease burden significantly mediated relationships between social asymmetry and episodic memory and executive function, whereas allostatic load did not.

Indexed as

Allostatic loadChronic diseaseCognitive agingSocial asymmetry

Identifiers

PMID42004491

DOI10.1016/j.bbih.2026.101232

PMCPMC13091159

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.