Theiler's murine encephalomyelitis virus as the infectious agent for a virally induced mouse model of Parkinson's disease.

Tae Wook Kang, Rahul Srinivasan, Candice Brinkmeyer-Langford, C Jane Welsh

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Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Tae Wook KangDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

Rahul SrinivasanDepartment of Neuroscience & Experimental Therapeutics, Texas A&M College of Medicine, Texas A&M University, College Station, TX, USA.

Candice Brinkmeyer-LangfordDepartment of Environmental and Occupational Health, Texas A&M Health Science Center School of Public Health, Texas A&M University, College Station, TX, USA.

C Jane WelshDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder with a prevalence of over ten million patients worldwide. The etiology of PD remains unclear but neuroinflammation specifically associated with viral infection has risen as a possible contributor to the disease. Classical animal models of PD reproduce certain pathophysiological outcomes such as the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc), but these models are limited by the need to inject harmful neurotoxins to induce disease-like symptoms. We present a virally induced neuroinflammatory model of PD in C57BL/6J mice using a naturally occurring pathogen, Theiler's murine encephalomyelitis virus (TMEV), as the infectious agent. This model offers a tool for advancing our understanding of PD pathogenesis and potential treatment options.

Indexed as

Disease modelDopaminergic neuronsNeuroinflammationParkinson's diseaseTheiler's murine encephalomyelitis virusTyrosine hydroxylaseViral infection

Identifiers

PMID42004492

DOI10.1016/j.bbih.2026.101230

PMCPMC13091451

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.