ArticleIranian journal of basic medical sciences2026
Improved bioavailability of raloxifene hydrochloride through nasal administration of poly (methyl vinyl ether-co-maleic acid) nanoparticles in ovariectomized rats.
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To improve the low bioavailability of Raloxifene hydrochloride (RH), which is just 2% through oral administration, an in situ mucoadhesive thermoreversible gel loaded with RH nanoparticles was formulated using Pluronic F127. Materials and Methods: Mucoadhesion of the gels was modulated using Carbopol 934, Xanthan gum, and HPMC K4M as mucoadhesive polymers. The formulations containing 18% Pluronic and 0.2% Xanthan gum or 0.5% HPMC were considered as the optimized formulation based on their pH, gelation temperature, mucoadhesive strength, gel strength, viscosity, drug content, histopathological, and pharmacodynamic studies in ovariectomized rats. Results: The gelation temperatures were 33.63±0.38 °C for Xanthan gum (0.2%) and 37.18±0.71 °C for HPMC (0.5%). Also, the 51758.67±62.17 dyn/cm Conclusion: These results suggest that the thermoreversible nasal gel formulation of RH can be used as a safe drug-delivery system.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.