ArticleBiochemistry and biophysics reports2026
Exercise rejuvenates bone marrow mesenchymal stem cells associated with the inhibition of inflammatory factors and senescence-related factors.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Review of Rejuvenation Strategies Targeting Mesenchymal Stem Cell Senescence and Their Impact on Bone Health and Regeneration.Current osteoporosis reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the effects of exercise on bone marrow stem cells (BMSCs) and determine underlying molecular network mechanisms through bioinformatics analysis combined experimental validation. Methods: Target genes related to exercise and BMSCs were retrieved from the Gene Cards database and deduplicated, then performed bioinformatics analysis including Venny analysis, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), protein-protein interaction (PPI) and cystoscope to find hub genes. In animal experiment, 9-month-old male C57BL/6J mice were subjected to 4 months of treadmill exercise training (12 m/min, 1 h/day, 5 days/week) and the BMSCs from femur were cultured in vitro, and cell viability, the expression of cell senescence-related factors (P16, P21) and inflammatory factors (IL-6, IL-1β) were detected, and the vital role of IL-6, IL-1β was determined in vitro study. Results: 131 common targets were found via Venn diagram analysis. The STRING database and Cytoscape software identified several core molecules such as IL-1β, IL6, TNF, and stat3, etc. GO enrichment analysis revealed that these common targets were primarily involved in biological processes such as negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, leukocyte chemotaxis, and positive regulation of protein phosphorylation; cellular components such as extracellular space and lysosome; and molecular functions such as receptor ligand activity and chemokine activity. KEGG pathway analysis showed that the related genes were enriched in pathways including diabetic cardiomyopathy, IL-17 signaling pathway, and HIF-1 signaling pathway. Moreover, treadmill exercise results in a significant cell viability increase, which is related to the inhibition of IL-1β, IL-6 and P16, P21. Whereas the knockdown of IL-1β, IL-6 confirmed their vital role in the status of BMSC's rejuvenation. Conclusion: The present data concluded that running exercise increase effectively the physical viability to rejuvenate BMSCs, and underlying mechanism is associated with the inhibition of inflammatory factors and senescence-related factors.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.