ArticleFrontiers in pharmacology2026
Exploring histone acetylation in ischemic stroke: CREBBP and CKAP4 as candidate biomarkers linked to histone acetylation networks.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Ischemic stroke (IS) is a severe cerebrovascular disorder. Histone acetylation is a key epigenetic modification that is markedly increased and closely associated with enhanced neuronal tolerance to ischemia. Therefore, identifying biomarkers involved in regulating histone acetylation is critical for elucidating the pathological mechanisms of IS and for developing novel diagnostic and therapeutic strategies. Methods: Transcriptomic data from patients with IS were analyzed to systematically identify the diagnostic biomarkers associated with histone acetylation regulation through an integrative framework combining differential expression analysis, weighted gene co-expression network analysis, multiple machine-learning algorithms, and receiver operating characteristic analysis. Furthermore, the potential biological functions and immune relevance were explored using bioinformatics approaches, including functional enrichment analysis, immune microenvironment evaluation, and disease association analysis. The expression levels of the candidate biomarkers were subsequently validated by reverse transcription quantitative polymerase chain reaction (RT-qPCR) in clinical blood samples. Results: A total of 44 histone-acetylation-related differentially expressed genes were identified, among which Conclusion:
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