Evidence map›Paper›PMID 42004609›Full record

Trial reportJBMR plus2026

Effects of cocoa extract supplementation on physical performance measures: results from the randomized controlled COcoa Supplement and Multivitamin Outcomes study.

Sharon H Chou, Nancy Cook, Eunjung Kim, Gregory Kotler, David A Ganz, Peggy M Cawthon, Allison Clar, Aladdin H Shadyab, JoAnn E Manson, Howard D Sesso and 2 more

Abstract readClinical Trial
In one paragraph

Trial report in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sharon H ChouDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA 02115, United States.ORCID https://orcid.org/0000-0003-2582-050X
Nancy CookHarvard Medical School, Boston, MA 02115, United States.
Eunjung KimHarvard Medical School, Boston, MA 02115, United States.
Gregory KotlerHarvard Medical School, Boston, MA 02115, United States.
David A GanzDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, United States.
Peggy M CawthonDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94115, United States.
Allison ClarHarvard Medical School, Boston, MA 02115, United States.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA 92093, United States.
JoAnn E MansonHarvard Medical School, Boston, MA 02115, United States.
Howard D SessoHarvard Medical School, Boston, MA 02115, United States.
Carolyn J CrandallDivision of General Internal Medicine and Health Services Research, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90024, United States.ORCID https://orcid.org/0000-0001-9441-0198
Meryl LeBoffDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA 02115, United States.ORCID https://orcid.org/0000-0001-5797-4947

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poor physical performance is associated with a higher risk of falls, fractures, and premature death among older adults. We determined whether supplementation with cocoa extract vs placebo or multivitamin/multimineral (MVM) vs placebo for 2 yr benefited physical performance measures. The COcoa Supplement and Multivitamin Outcomes Study was a double-blinded, placebo-controlled randomized trial of supplemental cocoa extract and/or MVM vs placebo for the primary prevention of cardiovascular disease and cancer in 21 442 US adults. This ancillary study was completed in a New England sub-cohort that underwent physical performance measurements, including grip strength, walking speed, standing balance, repeated chair stands, and timed-up and go (TUG) test, at baseline and 2-yr follow-up. In the clinic sub-cohort (

Indexed as

cocoa extractflavanolgrip strengthmultivitamin/multimineralphysical performanceShort Physical Performance Batterywalking speed

Identifiers

PMID42004609
PMCPMC13089503

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.