Evidence map›Paper›PMID 42004622›Full record

ArticleBioactive materials2026

Three-dimensional printed PCL/nHA scaffolds promote soft tissue functional fibrosis to repair chest wall defect via Piezo1/Ca

Yuanquan Zhang, Xing Li, Zijie Meng, Minghai Ma, Rou Huang, Xiao Liang, Sida Liu, Wenyuan Wei, Yangfan Huo, Yizhang Li and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yuanquan ZhangDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Xing LiDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Zijie MengState Key Laboratory for Manufacturing Systems Engineering, National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, 710049, Xi'an, China.
Minghai MaDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Rou HuangSchool of Advanced Materials and Nanotechnology, Xidian University, 710126, Xi'an, China.
Xiao LiangDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Sida LiuThe 940 Hospital of the Joint Logistic Support Force, 730050, Lanzhou, Gansu Province, China.
Wenyuan WeiState Key Laboratory for Manufacturing Systems Engineering, National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, 710049, Xi'an, China.
Yangfan HuoDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Yizhang LiDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Zhaowei GaoDepartment of Clinical Laboratory, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Hao GuoDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Jiawei XiuDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Yabo ZhaoDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Jiankang HeState Key Laboratory for Manufacturing Systems Engineering, National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, 710049, Xi'an, China.
Lijun HuangDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Xiaolong YanDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Lei WangDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The formation of a hardened fibrous membrane through in situ degradation of polycaprolactone (PCL) in soft tissues has emerged as a promising alternative to conventional rigid bone implants for chest wall reconstruction. However, strategies to enhance the mechanical integrity and biological performance of such fibrous constructs remain limited. While nano-hydroxyapatite (nHA) is known to promote osteoblast proliferation and mineralization, its role in regulating fibroblast behavior remains unclear, particularly within a dynamically strained environment mimicking respiratory motion. In this study, we developed PCL scaffolds incorporating various concentrations of nHA using fused deposition modeling (FDM). The PCL/10 wt% nHA scaffold exhibited optimal mechanical properties and significantly enhanced fibroblast proliferation, adhesion, and extracellular matrix deposition in vitro. Notably, higher nHA content led to excessive Piezo1 activation, resulting in Ca

Indexed as

Chest wall reconstructionPCL/nHA scaffoldPiezo1/Ca2+ signaling axisRespiratory dynamic environmentSoft tissue fibrosis

Identifiers

PMID42004622
PMCPMC13084373

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.