Evidence map›Paper›PMID 42004695›Full record

ArticlePeerJ2026

Efficacy and safety of tacrolimus combined with low-dose glucocorticoids

Xiaotao Ma, Jiayi Li, Xia Yang, Baoling Li, Tian Yao, Lifang Tian, Fuqian Lei, Xiaoyong Yu, Shohida Naimova, Sui Lin Cao and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaotao Ma *Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jiayi Li *Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xia YangDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Baoling LiDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Tian YaoDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Lifang TianDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Fuqian LeiDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xiaoyong YuDepartment of Nephrology, Shaanxi Traditional Chinese Medicine Hospital, Xi'an, Shaanxi, China.
Shohida NaimovaDepartment of Nephrology, Bukhara State Medical Institute, Bukhara, Uzbekistan.
Sui Lin CaoDepartment of Nephrology, Xi'an Gaoxin Hospital, Xi'an, Shaanxi, China.
Rongguo FuDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The treatment of adult minimal change disease (MCD) is challenging due to the side effects of high-dose and long-term glucocorticoid therapy as well as the frequent relapsing of the disease. Clinically, there is a demand for regimens that ensure rapid response and lower relapse rates, such as calcineurin inhibitors could fulfill this role. This study aims to compare the efficacy and safety of tacrolimus combined with low-dose glucocorticoids Methods: A retrospective cohort study was conducted on 59 adult patients diagnosed with MCD Results: At 24 weeks, the complete remission rates (90% Conclusions: Tacrolimus combined with low-dose glucocorticoids demonstrates comparable efficacy to high-dose glucocorticoids in inducing remission for adult-onset MCD, with a more favorable safety profile.

Indexed as

GlucocorticoidsImmunosuppressive AgentsNephrosis, LipoidPrednisoneTacrolimusAdultDose-Response Relationship, DrugDrug Therapy, CombinationFemaleHumansMaleMiddle AgedRecurrenceRemission InductionRetrospective StudiesTreatment OutcomeGlucocorticoidsImmunosuppressive AgentsPrednisoneTacrolimusAdultGlucocorticoidsMinimal change diseaseNephrotic syndromeTacrolimus

Identifiers

PMID42004695
PMCPMC13086028

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.