Evidence map›Paper›PMID 42004696›Full record

SynthesisPeerJ2026

Vitamin D supplementation in infertile men: a systematic review and meta-analysis of effects on semen quality and endocrine function.

Guoqing Zhang, Giribabu Nelli, See Ziau Hoe, Mukhri Hamdan

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guoqing ZhangDepartment of Obstetrics & Gynaecology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Giribabu NelliDepartment of Physiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
See Ziau HoeDepartment of Physiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Mukhri HamdanDepartment of Obstetrics & Gynaecology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the effects of oral vitamin D supplementation on semen parameters, reproductive hormones and fertility outcomes in infertile men. Methods: We searched PubMed, Cochrane Library, Web of Science, Scopus and Embase for studies published within the last 10 years. Randomized controlled trials (RCTs) and observational studies evaluating oral vitamin D supplementation in infertile men and reporting semen parameters, reproductive hormones and/or fertility outcomes were included. Risk of bias was assessed using RoB 2.0 (RCTs) and ROBINS-I (observational studies). Results: Eleven studies (eight RCTs and three observational studies; Conclusions: Vitamin D supplementation may improve selected semen parameters and testosterone levels in infertile men, particularly progressive sperm motility. However, current evidence does not demonstrate improved clinical fertility outcomes, and higher doses (>4,000 IU/day) do not appear to confer additional benefits. Larger, well-designed trials with standardized fertility endpoints are needed to confirm clinical efficacy.

Indexed as

Dietary SupplementsInfertility, MaleSemen AnalysisVitamin DFemaleHumansMalePregnancyRandomized Controlled Trials as TopicSperm CountSperm MotilityTestosteroneTestosteroneVitamin DMale infertilityPregnancy outcomeReproductive hormoneSemen parameterVitamin D supplementation

Identifiers

PMID42004696
PMCPMC13086023

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.