Evidence map›Paper›PMID 42004721›Full record

ArticlePeerJ2026

Four and a half Lin11, Isl-1, Mec-3(LIM) domain protein 1 (FHL1) regulates vascular remodeling in low-flow vein grafts.

Chaoqun Wang, Jiantao Chen, Guangxian Chen, Jianbo Liao, Suiqing Huang, Kangni Feng, Ziyin Ye, Mengya Liang, Zhongkai Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chaoqun Wang *Department of Cardiac Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jiantao Chen *Department of Cardiac Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Guangxian ChenDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jianbo LiaoNHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University, Guangzhou, China.
Suiqing HuangDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Kangni FengDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Ziyin YeDepartment of Pathology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Mengya LiangDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Zhongkai WuDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neointimal hyperplasia (NIH) is a critical determinant of long-term patency of vein grafts following coronary artery bypass grafting (CABG). The development of neointima is influenced by hemodynamic conditions. Our previous studies have demonstrated that four and a half LIM domain protein 1 (FHL1) effectively attenuates neointimal formation in vein grafts under normal flow conditions. However, the role of FHL1 in low-flow hemodynamic environments remains unclear. Elucidating the mechanisms underlying NIH in low-flow settings is essential for improving low-flow vein graft outcomes. Methods: The vein graft model was established in Sprague-Dawley (SD) rats, with low blood flow induced by ligation of the internal carotid artery. Then eointimal area was quantified using histological staining, while the expression of neointimal markers was assessed Results: Following internal carotid artery ligation, the mean blood flow velocity in the vein grafts decreased immediately ( Conclusion: In low-flow vein grafts, FHL1 may promote favorable vascular remodeling by inhibiting the MAPK signaling pathway, thereby attenuating neointimal cell phenotype switching and mitigating vascular inflammation.

Indexed as

Intracellular Signaling Peptides and ProteinsLIM Domain ProteinsMuscle ProteinsNeointimaVascular RemodelingAnimalsHyperplasiaJugular VeinsMaleRatsRats, Sprague-DawleyFhl1 protein, ratIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMuscle ProteinsFHL1Low-flowNeointimal hyperplasiaVein graft remodeling

Identifiers

PMID42004721
PMCPMC13089220

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.