Evidence map›Paper›PMID 42004816›Full record

ReviewTherapeutic advances in gastroenterology2026

Advancements in targeted therapy for gastric cancer.

Yihua Wang, Jie Li, Guanmo Liu, Chenggang Zhang, Pan Li, Weiming Kang, Xin Ye

Abstract readReview
In one paragraph

Review in Therapeutic advances in gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yihua WangDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.ORCID https://orcid.org/0009-0001-2837-128X
Jie LiDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0003-2555-6331
Guanmo LiuDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Chenggang ZhangDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Pan LiDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Weiming KangDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifu Yuan, Dongcheng District, Beijing 100730, People's Republic of China.ORCID https://orcid.org/0000-0002-6736-4728
Xin YeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifu Yuan, Dongcheng District, Beijing 100730, People's Republic of China.ORCID https://orcid.org/0000-0001-8355-4516

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) ranks among the most prevalent malignancies of the gastrointestinal system. For patients with advanced-stage disease undergoing surgical resection, postoperative 5-year survival rates remain critically low, typically below 20%. Contemporary therapeutic strategies encompass surgical intervention, cytotoxic chemotherapy, immune checkpoint blockade, and molecularly-targeted agents. Targeted therapeutics exert their effects by exploiting molecular vulnerabilities such as human epidermal growth factor receptor-2, Claudin 18.2, vascular endothelial growth factor/vascular endothelial growth factor receptor, fibroblast growth factor receptor 2, and N6-methyladenosine modification pathways, thereby suppressing tumor proliferation and offering improved clinical outcomes for advanced GC. These agents demonstrate significant potential in extending overall survival durations, underscoring their translational value and substantial research implications. This comprehensive review delineates recent advancements in GC-targeted therapies to inform precision oncology paradigms and guide future drug discovery initiatives.

Indexed as

CLDN18.2gastric cancerHER2targeted therapyVEGF/VEGFR

Identifiers

PMID42004816
PMCPMC13087351

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.