Evidence map›Paper›PMID 42004886›Full record

ArticleBiofilm2026

Synergistic tissue destruction by

Rima Nuwayhid, Nguyen Ngoc-Huyen, Norman Lippmann, Nadine Dietze, Laura Kursawe, Judith Kikhney, Annette Moter, Philipp Kobbe, Frank Siemers, Andreas Roth and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biofilm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rima NuwayhidDepartment of Orthopaedic, Trauma and Plastic Surgery, University Hospital Leipzig, 04103, Leipzig, Germany.
Nguyen Ngoc-HuyenDepartment of Upper Extremity Surgery and Microsurgery, Institute of Traumatology, Orthopedics and Plastic Surgery of Central Hospital 108, Hanoi, Viet Nam.
Norman LippmannInstitute of Medical Microbiology and Virology, University Hospital Leipzig, 04103, Leipzig, Germany.
Nadine DietzeInstitute of Medical Microbiology and Virology, University Hospital Leipzig, 04103, Leipzig, Germany.
Laura KursaweInstitute of Medical Microbiology and Virology, University Hospital Leipzig, 04103, Leipzig, Germany.
Judith KikhneyInstitute of Medical Microbiology and Virology, University Hospital Leipzig, 04103, Leipzig, Germany.
Annette MoterInstitute of Medical Microbiology and Virology, University Hospital Leipzig, 04103, Leipzig, Germany.
Philipp KobbeDepartment of Trauma and Reconstructive Surgery, Martin-Luther-University Halle-Wittenberg, 06120, Halle, Germany.
Frank SiemersDepartment of Plastic, Hand Surgery and Burn Care, BG Klinikum Bergmannstrost, 06112, Halle, Germany.
Andreas RothDepartment of Orthopaedic, Trauma and Plastic Surgery, University Hospital Leipzig, 04103, Leipzig, Germany.
Stefan LangerDepartment of Orthopaedic, Trauma and Plastic Surgery, University Hospital Leipzig, 04103, Leipzig, Germany.
Christina PempeDepartment of Orthopaedic, Trauma and Plastic Surgery, University Hospital Leipzig, 04103, Leipzig, Germany.
Olga KurowDepartment of Orthopaedic, Trauma and Plastic Surgery, University Hospital Leipzig, 04103, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staphylococci are common skin commensals that can transition into opportunistic pathogens, particularly in biofilm-associated and polymicrobial infections. However, how interspecies interactions modulate virulence remains poorly understood, partly due to a lack of human-relevant models. We adapted a human cell-based three-dimensional skin equivalent (3DSE) into a biofilm infection model using monospecies biofilms of

Indexed as

3D tissue engineeringBiofilmCytokine responsePolymicrobial infectionSkin modelStaphylococcus aureusStaphylococcus epidermidis

Identifiers

PMID42004886
PMCPMC13089071

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.