ArticleJournal of the Endocrine Society2026
Thyroid hormones are associated with pituitary and thyroid volume in a population-based study.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
There is increasing evidence that even a small variation in thyroid function, even within the reference range, is associated with adverse clinical outcomes. Furthermore, there exists a substantial interindividual variation of thyroid function even within euthyroid individuals suggesting an individual hypothalamus-pituitary-thyroid (HPT) axis setpoint. Here we assess potential contributions of the HPT axis organ volumes to the variation of thyroid hormones in the general population. Using linear regression models, we analyzed the association of circulating free T3, free T4, and log-transformed TSH levels with hypothalamus, pituitary gland, and log-transformed thyroid volume in a subsample of up to n = 3438 participants from the population-based Study of Health in Pomerania with a mean age 50.6 years, 44.6% female, and a mean TSH 1.38mU/L. Performing cross-sectional analyses at baseline, we observed inverse associations of pituitary volume with free T4 levels (
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