ArticleHealth science reports2026
Joint Influence of Recreational Physical Activity and Diet Quality on MAFLD: A National Study of Dose-Response and Synergy.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background and Aims: Utilizing data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES), this study examined the dose-response relationships and potential synergistic effects of physical activity (PA) and dietary quality (DQ) on the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) among US adults. Methods: A nationally representative sample of 6511 participants was analyzed. PA was quantified as weekly recreational physical activity time, and DQ was assessed using the Healthy Eating Index-2015. Weighted multivariable logistic regression models, adjusted for sociodemographic, metabolic, and behavioral confounders, were used to evaluate associations. Dose-response patterns were examined using smooth curve fitting and segmented regression. Results: Both higher PA and DQ were independently associated with reduced MAFLD risk (DQ: OR = 0.984, 95% CI = 0.981-0.987; PA: OR = 0.974, 95% CI = 0.969-0.978; both Conclusions: PA and DQ were independently associated with a lower MAFLD risk, with PA exhibiting a threshold effect (optimal at ~400 min/week) and DQ demonstrating cumulative benefits at higher scores. Combining high PA and high DQ yields the strongest protective effect, underscoring the importance of integrated lifestyle interventions for MAFLD prevention.
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