Evidence map›Paper›PMID 42005815›Full record

ArticleRegenerative biomaterials2026

Betaine based organ preservation solution alleviates renal allograft I/R injury by protecting endothelial cells.

Mingxing Yu, Shuo Li, Xu Duan, Yiran Wang, Tao Ming, Shaohua Wu, Xihe Wang, Zhongyang Shen, Xunfeng Zou, Deling Kong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mingxing YuResearch Institute of Transplant Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
Shuo LiResearch Institute of Transplant Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
Xu DuanResearch Institute of Transplant Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
Yiran WangResearch Institute of Transplant Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
Tao MingResearch Institute of Transplant Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
Shaohua WuClinical Laboratory, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
Xihe WangResearch Institute of Transplant Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
Zhongyang ShenResearch Institute of Transplant Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
Xunfeng ZouDepartment of General Surgery, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
Deling KongResearch Institute of Transplant Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
Tingting LanResearch Institute of Transplant Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Static cold preservation remains a cornerstone of transplantation, and high-performance organ preservation solutions, sharing the same goal as regenerative biomaterials, are indispensable for facilitating the regeneration and functional recovery of organs following transplantation. In this study, we developed a betaine-based organ preservation solution (BOPs), combined with the optimization of osmotic pressure components and energy support components. In the endothelial cell inflammation model, BOPs exhibited robust antioxidative and anti-apoptotic effects. Across multiple stages of kidney transplantation, including static cold storage, early reperfusion and the post-

Indexed as

anti-apoptoticbetaineischemia-reperfusion injuryorgan preservation solution

Identifiers

PMID42005815
PMCPMC13091617

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.