Comparative transcriptomics reveals differences in cortical cell type organization between metatherian and eutherian mammals.

Abstract read

In one paragraph

Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Update of
Comparative transcriptomics reveals shifts in cortical architecture at the metatherian/eutherian transition.2025

5 · Who and what money

Authors and funding

2 authors.

Ryan GorzekDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Joshua T TrachtenbergDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0002-5041-774X

Funding

Origins of plasticity in the establishment of binocular visionR01EY023871 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joshua Trachtenberg · 2013 to 2026

$5.4M

NEI NIH HHS R01 EY023871

6 · The paper itself

Abstract

The neocortex, a layered structure unique to mammals, supports higher-order functions, including perception, learning, and decision-making. While its laminar architecture is broadly conserved, the cell type-specific organization of the cortical column has not been compared across species that diverged early in mammalian evolution. To address this, we used single-nucleus RNA sequencing and spatial transcriptomics to compare gene expression, cell types, and laminar architecture in the primary visual cortex (V1) of metatherian (

Indexed as

columncomparativeevolutionneocortextranscriptomics

Identifiers

PMID42005962

DOI10.1093/pnasnexus/pgag055

PMCPMC13089494

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.