ArticleHuman mutation2026
A Combined Transcriptomic and Machine Learning Study Reveals PAX8 as a Promising Diagnostic Biomarker in Endometriosis.
Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endometriosis (EM) is a chronic, estrogen-dependent disease that lacks reliable noninvasive diagnostic biomarkers. This study was aimed at evaluating the diagnostic value of PAX8 using integrated transcriptomic and machine learning analyses. Methods: Transcriptomic data from the GSE141549 dataset were analyzed to identify differentially expressed genes (DEGs). Weighted gene coexpression network analysis (WGCNA), immune infiltration profiling, and functional enrichment (GO, KEGG, and GSEA) were conducted. Random forest (RF), support vector machine (SVM), and logistic regression (LR) models were trained and validated through five-fold cross-validation. Results: A total of 887 DEGs were identified, among which PAX8 was significantly downregulated in ectopic tissues and identified as a key diagnostic feature by both RF and WGCNA. GSEA revealed that PAX8-related gene sets were enriched in biological processes such as cilium organization and wound healing, and KEGG analysis indicated involvement in calcium signaling, JAK-STAT signaling, and focal adhesion pathways. Immune infiltration analysis further supported an immunomodulatory role of PAX8.
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