Evidence map›Paper›PMID 42006201›Full record

ArticleKidney international reports2026

Cognitive Impairment Predicts Adverse Outcomes in CKD.

Hélène Levassort, Yousra Hassan, Julie Boucquemont, Sophie Liabeuf, Solène M Laville, Céline Lange, Natalia Alencar de Pinho, Ziad A Massy, Marion Pépin, CKD-REIN Study Collaborators

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Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hélène LevassortGeriatric Department, University Medical Department 1, Assistance Publique - Hôpitaux de Paris (AP-HP), Ambroise Paré Hospital, University Hospital Group Paris Saclay, Boulogne-Billancourt, France.
Yousra HassanClinical Epidemiology Team, Centre for Research in Epidemiology and Population Health, Paris-Saclay University, Institut National de la Santé et de la Recherche Médicale U1018, Versailles Saint-Quentin University, Villejuif, France.
Julie BoucquemontClinical Epidemiology Team, Centre for Research in Epidemiology and Population Health, Paris-Saclay University, Institut National de la Santé et de la Recherche Médicale U1018, Versailles Saint-Quentin University, Villejuif, France.
Sophie LiabeufPharmacoepidemiology Unit, Department of Clinical Pharmacology, Amiens-Picardie University Medical Center, Amiens, France.
Solène M LavillePharmacoepidemiology Unit, Department of Clinical Pharmacology, Amiens-Picardie University Medical Center, Amiens, France.
Céline LangeClinical Epidemiology Team, Centre for Research in Epidemiology and Population Health, Paris-Saclay University, Institut National de la Santé et de la Recherche Médicale U1018, Versailles Saint-Quentin University, Villejuif, France.
Natalia Alencar de PinhoClinical Epidemiology Team, Centre for Research in Epidemiology and Population Health, Paris-Saclay University, Institut National de la Santé et de la Recherche Médicale U1018, Versailles Saint-Quentin University, Villejuif, France.
Ziad A MassyClinical Epidemiology Team, Centre for Research in Epidemiology and Population Health, Paris-Saclay University, Institut National de la Santé et de la Recherche Médicale U1018, Versailles Saint-Quentin University, Villejuif, France.
Marion PépinGeriatric Department, University Medical Department 1, Assistance Publique - Hôpitaux de Paris (AP-HP), Ambroise Paré Hospital, University Hospital Group Paris Saclay, Boulogne-Billancourt, France.
CKD-REIN Study Collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cognitive impairment (CI) affects self-management in chronic diseases, leading to poor decision-making, delayed care, and increased mortality. The specific impact of CI on adverse outcomes in chronic kidney disease (CKD) remains poorly explored. Methods: The French CKD - Renal Epidemiology and Information Network (CKD-REIN) cohort included 3033 patients with CKD stage 2 to 5 and 5 years of follow-up. CI was assessed using the Mini-Mental State Examination (MMSE), and estimated glomerular filtration rate (eGFR) was estimated using the CKD Epidemiology Collaboration creatinine equation. Cox models evaluated the risks of all-cause mortality, kidney replacement therapy (KRT) initiation, and major adverse cardiovascular (CV) events (MACEs). Results: A total of 3004 patients were included in the analysis (mean age: 67 years, mean eGFR: 34 ml/min per 1.73 m Conclusion: In CKD, a baseline MMSE score < 24 predicts higher overall-death, KRT initiation, and MACEs, relative to a baseline score > 26. These results highlight CI's prognostic value, and suggest that earlier detection could better personalize management, particularly for kidney and CV complications.

Indexed as

chronic kidney diseasecognitive impairmentkidney replacement therapymajor adverse cardiovascular eventmortality

Identifiers

PMID42006201
PMCPMC13088961

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.