ArticleFrontiers in endocrinology2026
Insulin resistance assessed by estimated glucose disposal rate and risk of coronary artery calcification in middle-aged participants without diabetes undergoing health check-ups.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and aims: Insulin resistance, assessed by estimated glucose disposal rate (eGDR), is linked to atherosclerosis, yet evidence primarily comes from diabetic populations. The aim of this study was to investigate the association between eGDR and coronary artery calcification (CAC) in non-diabetic adults. Methods: In this cross-sectional study, 4750 participants aged 40-65 years without diabetes were enrolled from Jinling Hospital between 2022 and 2024. CAC was assessed via CT scans. Multivariable Logistic regression and restricted cubic splines were used to analyze the relationship of eGDR with CAC prevalence and severity. Results: The mean age was 47.98 ± 6.61 years; 79.31% were male, and 665 participants (14.0%) had CAC. After multivariable adjustment, lower eGDR was significantly associated with higher CAC risk. Each 1-unit increase in eGDR was associated with a 9% risk reduction (OR = 0.91, 95% CI: 0.84-0.98, Conclusion: Lower eGDR is independently associated with increased prevalence and severity of CAC in non-diabetic middle-aged Chinese adults.
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