Evidence map›Paper›PMID 42006342›Full record

ArticleiScience2026

Decoding unchanged transcriptome of Alzheimer's disease reveals an NCAM1 mRNA switch as a potential biomarker.

Haotian Li, Sai Liu, Daoxin Miao, Long Chen, Yuan Sun, Guangji Wang, Zheying Zhu, Xinuo Li, Qiulun Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haotian LiState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Sai LiuState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Daoxin MiaoState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Long ChenState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Yuan SunState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Guangji WangState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Zheying ZhuSchool of Pharmacy, The University of Nottingham, NG72RD Nottingham, UK.
Xinuo LiState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Qiulun LuState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD), a neurodegenerative disease primarily affecting older adults, is characterized by changes in memory, behavior, and language. Although gene expression varies during AD progression, the molecular mechanisms underlying this variation remain unclear. RNA sequencing indicates that most genes exhibit minimal gene-level differential expression in AD but may relate to neuronal function. Our comprehensive analysis revealed that neural cell adhesion molecule 1 (NCAM1) underwent alternative splicing (AS) in AD. Notably, an isoform switch occurred from the long isoform (L-NCAM1), typical under normal conditions, to the short isoform (S-NCAM1) in AD. S-NCAM1 lacked the intracellular domain in L-NCAM1. Additionally, the S-NCAM1-to-L-NCAM1 ratio increased in the hippocampus of amyloid precursor protein (

Indexed as

Cellular neuroscienceClinical neuroscienceHealth sciencesMolecular neuroscienceNeuroscience

Identifiers

PMID42006342
PMCPMC13090632

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.