ArticleiScience2026
Transcriptional noise sets fundamental limits to decoding circadian clock phase from single-cell RNA snapshots.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Unifying theories in high-dimensional biophysics: approaches, challenges and opportunities.NPJ systems biology and applications · 2026Article
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Authors and funding
4 authors.
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Abstract
The circadian clock drives rhythmic physiological variations, making accurate clock-phase measurement essential. Single-sample phase inference from bulk RNA is an exciting alternative to time-series methods, but its applicability to single cells remains unclear. Using multiplexed smFISH to quantify up to six core-clock genes in mouse fibroblasts, combined with a Gaussian process-based algorithm, we show that even with minimal technical dropouts, transcriptional noise in core-clock genes prevents reliable single-cell phase estimation. Simulations predict that measuring
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.