Mediation of coronary heart disease risk by genetic, socio-environmental, and lifestyle factors across racial groups.

Mohammadreza Naderian, Kristjan Norland, Keyue Ding, Ozan Dikilitas, Iftikhar J Kullo

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Article in American journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mohammadreza NaderianDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

Kristjan NorlandDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

Keyue DingDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

Ozan DikilitasDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

Iftikhar J KulloDivision of Cardiovascular Medicine, the Cardiovascular Research Center and the Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We investigated the extent to which differences in coronary heart disease (CHD) risk between self-identified race/ethnicity (SIRE) groups are mediated by genetic, socio-environmental, and lifestyle factors. Methods: In UK Biobank, we estimated genetic susceptibility for CHD using a polygenic risk score (PRS Results: Of 382,475 participants (55.6 ± 8.1 years, 57.5 % female, 94.9 % White, 1.7 % Asian/Asian British, 1.6 % Black/Black British, and 0.3 % Chinese), 9679 (2.5 %) had an incident CHD event, during 10 years of follow-up. The adjusted hazard ratios (HR) and 95 % confidence intervals (CIs) for a 1 SD increase in PSS Conclusions: Socio-environmental and lifestyle factors had a stronger mediating effect than genetic factors on the association between SIRE and CHD in the UK Biobank. These findings advance our understanding of factors underlying differences in CHD risk across SIRE groups.

Indexed as

Coronary heart diseaseGenetic risk factorsHealth disparitiesRaceSocial determinants of health

Identifiers

PMID42006424

DOI10.1016/j.ajpc.2026.101409

PMCPMC13084104

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LicenceCC BY-NC-ND

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