ArticleJournal of traditional and complementary medicine2026
Chemical characterization of Jing Guan Fang and its application in alleviating coronavirus envelope protein-induced proinflammatory responses
Article in Journal of traditional and complementary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Phytochemical Profiling and Proteomic Insights into the Anti-Inflammatory Effects of Jing Guan Fang in LPS-Stimulated Macrophages.Antioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aim: Jing Guan Fang (JGF) is an herbal formulation developed for the prevention of COVID-19 via SARS-CoV-2 infection. In this study, we aimed to clarify the anti-inflammatory effects of JGF on macrophages stimulated by the SARS-CoV-2 envelope protein (2-E) both Experimental procedure: Results and conclusions: The mouse model showed oral JGF administration could sufficiently reduce 2-E-stimulated proinflammatory factors in the bronchoalveolar lavage and blood serum. Moreover, JGF suppressed the 2-E-induced NO, TNF-α, and IL-6 production as well as the expression of iNOS and COX-2 in murine typical and alveolar macrophages. Mechanistically, JGF attenuated 2-E-mediated phosphorylation of STAT3 and ERK1/2 signaling pathways. Furthermore, baicalin and wogonoside, key components of JGF, demonstrated potent efficacy. To our knowledge, this is the first study to show that JGF mitigates 2-E-induced proinflammatory responses via modulation of STAT3 and ERK signaling, supporting its potential as a therapeutic herbal formulation against coronavirus E protein-related cytokine storms.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.