ArticleJournal of traditional and complementary medicine2026
Coptidis Rhizoma extract mitigates sleep deprivation-induced cognitive impairment and neurodegeneration: Insights into hormonal, glymphatic, and molecular mechanisms.
Article in Journal of traditional and complementary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: and Aim: Coptidis Rhizoma extract (CRE) is a traditional herbal medicine commonly used to treat insomnia and cognitive deficits. However, its protective effects and underlying molecular mechanisms in conditions such as sleep deprivation (SD) are not fully understood. Experimental procedure: This study intended to elucidate these mechanisms by combining functional assessments, imaging techniques, and genomic analyses in an animal model of sleep fragmentation-induced cognitive impairment. CRE's efficacy was compared with melatonin, an established neuroprotective agent. Results and conclusion: Our results demonstrated that SD significantly impaired cognitive functions and induced oxidative stress, inflammation, and multiple forms of neuronal cell death. Additionally, SD disrupted growth hormone (Gh) and hemoglobin (Hb) synthesis, impaired glymphatic clearance, and promoted accumulation of amyloid β-peptide (Aβ
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