Association of caspase-3 with thyroid hormone levels in patients with hypothyroidism - A hospital-based study.

Sathwika Shetty, Sindhu, Poornima Ajay Manjrekar, Sowndarya Kollampare, Janice Dsa

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Article in EJIFCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Sathwika ShettyDepartment of Biochemistry, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.

SindhuDepartment of Biochemistry, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.ORCID https://orcid.org/0000-0003-4267-6589

Poornima Ajay ManjrekarDepartment of Biochemistry, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.

Sowndarya KollampareDepartment of Biochemistry, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.

Janice DsaDepartment of Biochemistry, A.J. Institute of Medical Sciences & Research Centre, Mangalore, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This hospital-based prospective study examined the relationship between thyroid hormone levels and serum levels of caspase-3, a critical marker of apoptosis, in 183 patients diagnosed with hypothyroidism. Methods: Serum caspase-3 concentrations were measured using a human caspase-3 ELISA kit. Elevated caspase-3 levels indicate increased apoptotic activity. Results: In the overall cohort, the serum caspase-3 levels were not significantly correlated with the thyroid hormone level. However, among patients with mildly elevated TSH (Group I), caspase-3 levels were inversely correlated with T3 (r = -0.319, p < 0.05) and T Conclusion: The relationship between thyroid hormones and apoptosis appears to be both age- and severity-dependent. While thyroid hormones are inversely associated with apoptotic activity in mild hypothyroidism, age independently influences caspase-3 in younger individuals and T

Indexed as

ApoptosisCaspase-3Thyroid hormonesThyroid stimulating hormone

Identifiers

PMID42006496

PMCPMC13088417

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LicenceCC BY-NC

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.