Intranasally delivered fucoidan nanozyme-decorated photosynthetic

Andrew E-Y Chuang, Yo-Lin Chen, Chia-Hung Liu, Hieu Trung Nguyen, Tsung-Jen Wang, I-Chan Lin

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew E-Y ChuangGraduate Institute of Biomedical Materials and Tissue Engineering, International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, New Taipei City, 235603, Taiwan.

Yo-Lin ChenGraduate Institute of Biomedical Materials and Tissue Engineering, International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, New Taipei City, 235603, Taiwan.

Chia-Hung LiuDepartment of Urology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.

Hieu Trung NguyenDepartment of Orthopedics and Trauma, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, 700000, Viet Nam.

Tsung-Jen WangDepartment of Ophthalmology, Taipei Medical University Hospital, Taipei, 11031, Taiwan.

I-Chan LinDepartment of Ophthalmology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a leading cause of vision loss and is strongly associated with microvascular pathology and retinal hypoxia. Here, we report an intranasally delivered microalgae drug delivery system, Chlamydomonas@Pro-Fu-PEDOT nanozymes (CHL@Pro-Fu-PEDOT-NZs), engineered to target retinal injury. Under 660-nm red-light irradiation, the platform exploits the photosynthetic activity of Chlamydomonas to generate bioelectric cues and therapeutic gases (O

Indexed as

Chlamydomonas@-Poly(3,4- ethylenedioxythiophene)/protamine/fucoidan nanozymeDiabetic retinopathyImmunityMitigating hypoxiaP-selectin targetingVascularization

Identifiers

PMID42006715

DOI10.1016/j.mtbio.2026.103060

PMCPMC13089147

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.