ArticleAmerican journal of translational research2026
Comparable efficacy and safety of bridging therapy versus direct mechanical thrombectomy in anterior circulation large vessel occlusion stroke.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo compare the clinical and procedural outcomes, as well as complication rates, between bridging therapy (BT) and direct mechanical thrombectomy (D-MT) in patients with acute ischemic stroke (AIS) due to anterior circulation large vessel occlusion (LVO).
methodsIn this retrospective cohort study, 169 patients who underwent endovascular therapy (EVT) between January 2021 and January 2024 were included. Patients were divided into a BT group (n=96, intravenous alteplase followed by thrombectomy) and a D-MT group (n=73, thrombectomy alone). Baseline characteristics, procedural data, and 90-day functional outcomes were compared. Multivariable logistic regression identified predictors of 90-day favorable outcome (modified Rankin Scale score 0-2).
resultsBaseline characteristics were balanced between the groups (all
conclusionBT and D-MT demonstrate comparable efficacy and safety in treating anterior circulation LVO. The choice of strategy should consider patient-specific factors such as baseline neurological status and collateral circulation, rather than presumed superiority of either modality.
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