ArticleAmerican journal of translational research2026
Upregulated lncRNA XIST drives trophoblast dysfunction through targeting miR-545-5p/POU2F1 axis in recurrent spontaneous abortion.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the specific role of long non-coding RNA (lncRNA) XIST in recurrent spontaneous abortion (RSA).
methodsPlacental tissue samples from RSA patients and healthy controls were obtained to assess expression of the XIST/miR-545-5p/POU2F1 axis. Functional assays evaluating cell proliferation, apoptosis, and invasion, as well as nuclear factor kappa B (NF-κB) pathway activity, were performed in HTR-8/Svneo trophoblasts following transfection with short hairpin RNA (shRNA), miRNA mimics, or inhibitors. The targeting relationship among these molecules was verified through dual luciferase reporter gene assays. An RSA mouse model was established to study the effects of XIST knockdown on this molecular axis and pregnancy outcomes
resultsIn clinical RSA samples, lncRNA XIST expression was significantly upregulated. Knockdown of XIST in trophoblasts led to enhanced cell proliferation and invasion while reducing cell apoptosis. In the RSA mouse model, suppression of XIST decreased the embryonic resorption rate and improved pregnancy outcomes. Mechanistic studies revealed that XIST acts as a competing endogenous RNA that sponges miR-545-5p, thereby relieving repression of its downstream target POU2F1. Dysregulation of the XIST/miR-545-5p/POU2F1 axis contributed to trophoblast dysfunction and RSA pathogenesis through activation of the pro-inflammatory NF-κB signaling pathway.
conclusionThese findings suggest that lncRNA XIST may serve as a potential prognostic marker for RSA and promote disease progression via the miR-545-5p/POU2F1 regulatory axis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.