Evidence map›Paper›PMID 42007214›Full record

ArticleJournal of the National Cancer Center2026

Exploring the genetic overlap between obstructive sleep apnea and prostate cancer.

Allan Saj Porcacchia, Mariana Moyses-Oliveira, Gabriel Natan Pires, Monica Levy Andersen, Sergio Tufik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Center, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Allan Saj PorcacchiaDepartamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Mariana Moyses-OliveiraInstituto do Sono, Associação Fundo de Incentivo à Pesquisa (AFIP), São Paulo, Brazil.
Gabriel Natan PiresDepartamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Monica Levy AndersenDepartamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Sergio TufikDepartamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Studies have highlighted the possible association between obstructive sleep apnea (OSA) and an increased risk of cancer, especially prostate cancer. However, the extent to which genes that are found in both conditions contribute to their comorbidity is unclear. The aim of this study was to identify risk genes present in both conditions. Methods: Genes common to both conditions were identified and the statistical significance of the overlap was assessed. Pathway enrichment and protein-protein interaction analyses were performed on the intersecting gene set. Results: There were 68 common genes, more than would be expected by random effects. This intersect list was associated mainly with hypoxia, apoptosis, oxidative stress, and cell cycle proliferation, or cell damage. A 17-node protein interaction network highlighted key proteins involved in these enriched pathways. Conclusions: The results of the analysis indicated a common molecular etiology underlying this comorbidity. Proliferation, apoptosis, and hypoxia pathways were significantly enriched among the overlapping genes, suggesting their role in pathophysiological processes.

Indexed as

Genetic riskHypoxiaObstructive sleep apneaProstate cancerSleep

Identifiers

PMID42007214
PMCPMC13083649

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.