ArticleJournal of biomedical optics2026
Noninvasive diffuse optical monitoring of cerebral blood flow and oxygenation responses to intermittent hypoxia in neonatal rats.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Significance: Intermittent hypoxia (IH) is common in preterm neonates and can cause hypoxic-ischemic brain injury. Simultaneous monitoring of cerebral blood flow (CBF) and oxygenation is essential to detect oxygen delivery-extraction mismatches and guide intervention. Aim: We aimed to adapt and test an innovative diffuse speckle contrast flow oximetry (DSCFO) system for continuous monitoring of cerebral hemodynamics during IH in neonatal rats, a model approximating human neonates. Approach: Two compact laser diodes and a miniature CMOS camera were integrated into a fiber-free probe for continuous monitoring of changes in relative CBF (rCBF) and oxy- and deoxy-hemoglobin concentrations (Δ[HbO Results: Sham rats maintained stable cerebral hemodynamics under normoxia, whereas IH rats exhibited pronounced periodic fluctuations during IH. Hypoxic episodes caused instantaneous decreases in rCBF and Conclusions: We demonstrate an affordable, noninvasive, wearable, fiber-free DSCFO system for continuous monitoring of rCBF,
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