ArticleLeukemia research reports2026
"Catch-Up Vaccinations Post-Stem Cell Transplant: A case series and review of the literature".
Article in Leukemia research reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 authors.
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Abstract
Stem cell transplantation (SCT), including autologous and allogeneic approaches, is a potentially curative therapy for various hematologic malignancies and selected non-malignant disorders. Autologous stem cell transplantation (ASCT) is an established curative treatment for hematologic malignancies, including Hodgkin lymphoma (HL). Non-Hodgkin Lymphoma (NHL), and Multiple Myeloma (MM), but infectious complications remain a major challenge. Vaccination is an essential strategy to reduce the risk of vaccine-preventable infections following transplant. This case series describes immunocompromised patients with relapsed or refractory hematologic malignancies who underwent ASCT and were referred for post-transplant immunization. We present a catch-up and COVID-19 vaccination schedule using minimum recommended intervals, with emphasis on immunocompromised hosts and post-ASCT maintenance therapies. Post-ASCT maintenance therapies such as rituximab may impair humoral responses and reduce vaccine immunogenicity; however, current guidelines support prioritized use of inactivated vaccines, including pneumococcal conjugate vaccines (PCV-13) followed by Pneumococcal Polysaccharide vaccine (PPSV-23) and annual inactivated influenza vaccination. Vaccination timing should consider B-cell-depleting therapies to optimize immune response, while live attenuated vaccines remain contraindicated during ongoing immunosuppression. Vaccines were well tolerated, with only mild injection-site reactions reported.
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