ReviewDrug design, development and therapy2026
Pharmacological Mechanisms and Clinical Applications of Oxycodone in Cancer Pain Management: A Narrative Review.
Review in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pharmacokinetics of intravenous oxycodone hydrochloride in perioperative patients with liver cancer.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer pain significantly impairs quality of life in oncology patients and remains inadequately managed globally. This narrative review examines the pharmacokinetic and pharmacodynamic properties of oxycodone, the impact of CYP2D6 genetic polymorphism on its metabolism, and the EGFR-dependent bidirectional effects of oxycodone on cancer cell biology. Critically, these bidirectional tumor cell effects were observed exclusively under supraphysiological in vitro concentrations (0.01-10 µM), far exceeding clinical therapeutic plasma levels (nM range), and are insufficient to alter current clinical guidelines. We further evaluate oxycodone's effects on tumor angiogenesis and immune function, and summarize clinical evidence from postoperative analgesia studies in breast, colorectal, gastric, lung, and liver cancer patients, supporting oxycodone as a preferred option for perioperative analgesia in abdominal and thoracic cancer surgery. The limitations of oxycodone in chronic neuropathic and bone metastasis pain are discussed, alongside recent advances in oxycodone formulation development and novel analgesics in China. Individualized treatment strategies integrating pharmacogenomic profiles and multimodal approaches are encouraged.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.