Evidence map›Paper›PMID 42008137›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

New mercaptoacrylate derivatives and other constituents from the stem bark of Senegalia polyacantha: in vitro antioxidant and antiplasmodial activities with in silico target validation.

Hermann Fomena, Gabrielle Ange Amang À Ngnoung, Peron Bosco Leutcha, Jeannette Nina Magoudjou Pekam, Relwendé Justin Ouédraogo, Hamadou Mamoudou, Karelle Audrey Tchapgang Tchoudji, Jean Noël Nyemb, Shafi Ullah Khan, Michael Hermann Kengne Kamdem and 5 more

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hermann FomenaDepartment of Chemistry, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon.
Gabrielle Ange Amang À NgnoungDepartment of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, P. O. Box 2701, Douala, Cameroon.
Peron Bosco LeutchaDepartment of Chemistry, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon. peron.leutcha@gmail.com.
Jeannette Nina Magoudjou PekamLaboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé1, , P.O. Box 812, Yaoundé, Cameroon.
Relwendé Justin OuédraogoResearch and Development Laboratory for Phytomedicines and Medicines (LRD/PM), National Centre for Scientific and Technological Research (CNRST), Institute for Health Sciences Research (IRSS), P.O. Box 7047 Ouaga 03, Ouagadougou, Burkina Faso.
Hamadou MamoudouDepartment of Biological Sciences, Biochemistry, Bioinformatics, and Bioactive Compounds for Health Promotion, Research Unit, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon.
Karelle Audrey Tchapgang TchoudjiLaboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé1, , P.O. Box 812, Yaoundé, Cameroon.
Jean Noël NyembDepartment of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, University of Maroua, P.O. Box 08, Kaélé, Cameroon.
Shafi Ullah KhanInserm U1086 ANTICIPE (Interdisciplinary Research Unit for Cancer Prevention and Treatment), UNICAEN, Normandie University, 14076, Caen, France.
Michael Hermann Kengne KamdemCentre for Natural Products Research, Department of Chemical Sciences, Doornfontein Campus, University of Johannesburg, P.O. Box 17011, Johannesburg, 2028, South Africa.
Derek Tantoh NdintehCentre for Natural Products Research, Department of Chemical Sciences, Doornfontein Campus, University of Johannesburg, P.O. Box 17011, Johannesburg, 2028, South Africa.
Refilwe MatshitseDepartment of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, 0204, South Africa.
Alain Meli LannangDepartment of Chemical Engineering, School of Chemical Engineering and Mineral Industries, University of Ngaoundere, P.O. Box 454, Ngaoundere, Cameroon.
Xavier Siwe NoundouDepartment of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, 0204, South Africa. xavier.siwenoundou@smu.ac.za.
Yves Oscar Nganso DitchouDepartment of Chemistry, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon. nganso_yves@yahoo.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimalarial resistance remains one of the main obstacles in the fight against malaria, which continues to be a leading cause of death in Africa. This study aimed to evaluate the antiplasmodial, cytotoxic, and antioxidant properties of the extracts and compounds from the stem bark of Senegalia polyacantha (Willd.) Seigler & Ebinger (syn. Acacia polyacantha Willd.). The DCM/MeOH crude extract (SPDM) of S. polyacantha was further extracted with EtOAc (SPEA) and chromatographed, leading twenty-four compounds (1-24) which were all characterized using NMR and MS data. The SPDM, SPEA, and compounds (1-24) were assessed for their in vitro/in silico (PDB Id: 7QC1) antiplasmodial activities against asexual-blood stages of chloroquine-sensitive (3D7) and multiresistant (Dd2) strains of Plasmodium falciparum, as well as for their cytotoxic activities on Vero and RAW 264.7 and antioxidant potential using DPPH, ABTS, and FRAP assays. Compounds 1 and 2 were identified as previously unreported E/Z isomeric mercaptoacrylate derivatives, while compounds 3-24 were known. The antiplasmodial activity ranged from IC

Indexed as

AntimalarialsAntioxidantsPlant ExtractsPlasmodium falciparumAnimalsBiphenyl CompoundsCell SurvivalChlorocebus aethiopsHumansMiceMolecular Docking SimulationPicratesPlant BarkPlant StemsVero CellsAntimalarialsAntioxidantsBiphenyl CompoundsPicratesPlant ExtractsAcacia polyacanthaAntioxidant activityAntiplasmodial activityMercaptoacrylate derivativeMolecular dockingPlasmodium falciparumSenegalia polyacantha

Identifiers

PMID42008137

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.