Evidence map›Paper›PMID 42008671›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A discrete serotonergic circuit involved in the generation of tinnitus behavior.

Meng-Ting Yu, Zhen-Yu Dai, Si-Xin Wang, Ke-Jian Wang, Chun-Hui Qin, Yi-Mei Zhou, Xiao-Tao Guo, Chun-Chen Pan, Jia-Qiang Sun, Jing-Wu Sun and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Meng-Ting Yu *School of Life Sciences and Medical Engineering, Anhui University, Hefei 230601, China.
Zhen-Yu Dai *School of Life Sciences and Medical Engineering, Anhui University, Hefei 230601, China.
Si-Xin Wang *School of Life Sciences and Medical Engineering, Anhui University, Hefei 230601, China.ORCID 0009-0009-8584-2955
Ke-Jian WangSchool of Life Sciences and Medical Engineering, Anhui University, Hefei 230601, China.
Chun-Hui QinSchool of Life Sciences and Medical Engineering, Anhui University, Hefei 230601, China.
Yi-Mei ZhouSchool of Life Sciences and Medical Engineering, Anhui University, Hefei 230601, China.
Xiao-Tao GuoDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Chun-Chen PanDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Jia-Qiang SunDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Jing-Wu SunDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.ORCID 0009-0002-3715-4794
Wei-Heng ChenDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Yan JinDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0002-9644-6458
Qin-Wei WuSchool of Life Sciences and Medical Engineering, Anhui University, Hefei 230601, China.ORCID 0009-0003-7561-308X
Laurence O TrussellOregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0003-1171-2356
Zheng-Quan TangSchool of Life Sciences and Medical Engineering, Anhui University, Hefei 230601, China.ORCID 0000-0003-1691-6358

Funding

Synaptic mechanisms in the auditory system (Administrative Supplement)R01DC004450 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI LAURENCE O TRUSSELL · 1999 to 2026
$10.6M
HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) RO1DC0044050MOST | National Natural Science Foundation of China (NSFC) 32271059 82071061NIDCD NIH HHS R01 DC004450
6 · The paper itself

Abstract

Although dysregulated serotonergic neurotransmission has been implicated in the pathophysiology of tinnitus, the precise neural circuit mechanisms underlying this complex sensory neurological disorder remain elusive. In the current study, we investigated whether a serotonergic input from the dorsal raphe nucleus (DRN) to the dorsal cochlear nucleus (DCN), a key auditory brain region whose hyperactivity is associated with tinnitus, modulates behaviors in mice consistent with the presence of tinnitus. Using neural tracing and viral-genetic methods, we identified an anatomically and functionally defined serotonergic subpopulation in the DRN that projects to the DCN (5-HT

Indexed as

Dorsal Raphe NucleusSerotonergic NeuronsSerotoninTinnitusAnimalsCochlear NucleusMaleMiceMice, Inbred C57BLNoiseOptogeneticsReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2ASerotonin5-HTdorsal cochlear nucleusdorsal raphe nucleushyperactivitytinnitus behavior

Identifiers

PMID42008671
PMCPMC13123803

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.