Evidence map›Paper›PMID 42008759›Full record

ArticleChemistry & biodiversity2026

Anticancer Potential of Piericidin A1 and Derivatives Isolated From Streptomyces sp. Associated With Palythoa variabilis From Brazilian Reefs.

Bianca Del B Sahm, Katharine G D Florêncio, Francisco C L Pinto, Ana I V Maia, Carlos A M Rocha, Paula C Jimenez, Otília D L Pessoa, Tito M C Lotufo, Leticia V Costa-Lotufo, Diego V Wilke

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bianca Del B SahmDepartamento De Farmacologia, Universidade De São Paulo, São Paulo, São Paulo, Brazil.
Katharine G D FlorêncioNúcleo de Pesquisa e Desenvolvimento de Medicamentos, Departamento De Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
Francisco C L PintoDepartamento De Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
Ana I V MaiaDepartamento De Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
Carlos A M RochaCoordenação de Recursos Pesqueiros e Agronegócio, Instituto Federal de Educação, Ciência e Tecnologia do Pará, Belém, Pará, Brazil.
Paula C JimenezInstituto Do Mar, Universidade Federal de São Paulo, Santos, São Paulo, Brazil.
Otília D L PessoaDepartamento De Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
Tito M C LotufoInstituto Oceanográfico, Universidade De São Paulo, São Paulo, São Paulo, Brazil.
Leticia V Costa-LotufoDepartamento De Farmacologia, Universidade De São Paulo, São Paulo, São Paulo, Brazil.
Diego V WilkeNúcleo de Pesquisa e Desenvolvimento de Medicamentos, Departamento De Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0001-9481-6702

Funding

CAPESCNPq
6 · The paper itself

Abstract

Marine holobionts are an important source of bioactive natural products. Building on our previous studies of cytotoxic compounds from zoantharians of the genus Palythoa, we investigated the anticancer potential of bacteria associated with Palythoa variabilis. Ten culturable bacterial strains were isolated and screened for cytotoxic activity against metastatic prostate cancer cells (PC-3/M) using the MTT assay. Among them, the crude extract of strain BRA-035, identified as Streptomyces sp., showed the most promising bioactivity profile and was selected for cytotoxicity-guided fractionation. This approach enabled the isolation of piericidin A1 (1) and the identification of two additional piericidin derivatives (2 and 3). piericidin A1 exhibited strong and selective cytotoxicity, with IC

Indexed as

AnthozoaAntineoplastic AgentsPyridinesStreptomycesAnimalsBrazilCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMaleMiceMolecular StructureStructure-Activity RelationshipAntineoplastic Agentspiericidin APyridinesanticancerholobiomePalythoapiericidinzoantharians

Identifiers

PMID42008759
PMCPMC13095201

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.