ReviewBlood reviews2026
Environmental exposures and multiple myeloma risk: A contemporary review of epidemiologic associations and mechanistic plausibility.
Review in Blood reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
7 authors.
Funding
Abstract
Despite major advances in the molecular characterization and treatment of multiple myeloma (MM), the factors driving disease onset remain poorly defined. Environmental influences represent a critical but underexplored component. Epidemiologic studies have associated a range of environmental and occupational exposures with increased MM risk, including pesticides, dioxins, and combustion byproducts, with experimental data supporting biologic plausibility through mechanisms such as oxidative stress, DNA damage, and aryl hydrocarbon receptor signaling. However, the available evidence is heterogeneous and largely associative, limiting causal inference. In this review, we synthesize current epidemiologic and mechanistic evidence linking environmental exposures to MM risk. We also highlight key methodological gaps and future directions, including the need for more precise exposure assessment, biospecimen-linked cohorts, and integrative studies that connect environmental data with disease biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.