Evidence map›Paper›PMID 42009759›Full record

ArticleNature microbiology2026

MoCox6 is a regulator of mitophagy and a druggable target in Magnaporthe oryzae.

Ming-Hua Wu, Ya-Nan Lv, Hui Li, Hui Qian, Yun-Yun Wei, Yun-Ran Zhang, Shuang Liang, Xue-Ming Zhu, Jian-Ping Lu, Maurizio Del Poeta and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ming-Hua WuState Key Laboratory for Quality and Safety of Agro-Products, Zhejiang Provincial Key Laboratory of Agricultural Microbiomics, Institute of Biotechnology, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0009-0001-8121-3272
Ya-Nan LvState Key Laboratory for Quality and Safety of Agro-Products, Zhejiang Provincial Key Laboratory of Agricultural Microbiomics, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Hui LiCollege of Life Sciences, Zhejiang University, Hangzhou, China.
Hui QianCollege of Plant Protection, Shandong Agricultural University, Taian, China.
Yun-Yun WeiCollege of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, China.
Yun-Ran ZhangXianghu Laboratory, Hangzhou, China.
Shuang LiangState Key Laboratory for Quality and Safety of Agro-Products, Zhejiang Provincial Key Laboratory of Agricultural Microbiomics, Key Laboratory of Agricultural Microbiome (MARA), Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Xue-Ming ZhuState Key Laboratory for Quality and Safety of Agro-Products, Zhejiang Provincial Key Laboratory of Agricultural Microbiomics, Key Laboratory of Agricultural Microbiome (MARA), Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Jian-Ping LuCollege of Life Sciences, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0001-9601-0040
Maurizio Del PoetaDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Zong-Hua WangInstitute of Oceanography, Minjiang University Fuzhou, Fujian, China.ORCID http://orcid.org/0000-0002-0869-9683
Yong-Hwan LeeDepartment of Agricultural Biotechnology and Global Plant Immunity Research Center, Seoul National University Seoul, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-2462-1250
Naweed I NaqviTemasek Life Sciences Laboratory, and the National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-3619-4906
Richard A WilsonDepartment of Plant Pathology, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID http://orcid.org/0000-0002-7754-7712
Daniel J KlionskyLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-7828-8118
Fu-Cheng LinState Key Laboratory for Quality and Safety of Agro-Products, Zhejiang Provincial Key Laboratory of Agricultural Microbiomics, Institute of Biotechnology, Zhejiang University, Hangzhou, China. fuchenglin@zju.edu.cn.ORCID http://orcid.org/0000-0002-4127-8143
Xiao-Hong LiuState Key Laboratory for Quality and Safety of Agro-Products, Zhejiang Provincial Key Laboratory of Agricultural Microbiomics, Institute of Biotechnology, Zhejiang University, Hangzhou, China. xhliu@zju.edu.cn.ORCID http://orcid.org/0000-0002-7466-1261

Funding

The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
Lipid-mediated fungal pathogenesisR01AI125770 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI DEL POETA, MAURIZIO · 2016 to 2025
$6.2M
BLRD VA IK6 BX005386National Natural Science Foundation of China (National Science Foundation of China) 32472500NIAID NIH HHS R01 AI125770NIGMS NIH HHS R35 GM131919ORD VA IK6 RD001331
6 · The paper itself

Abstract

Mitophagy is a selective autophagic process that maintains cellular homeostasis by degrading damaged mitochondria and is a promising antifungal target. However, few inner mitochondrial membrane (IMM) regulators of mitophagy are known. Here we identify cytochrome c oxidase subunit 6 (MoCox6) as an IMM regulator in Magnaporthe oryzae that binds MoAtg5 and MoAtg14 following outer mitochondrial membrane rupture to mediate mitophagy. MoSirt5 regulates this process by desuccinylating MoCox6 at K144. Structural analysis revealed that residue D95 at the MoSirt5-MoCox6 interface mediates the dual role of MoCox6 in mitophagy and mitochondrial metabolic competence. Deletion of the COX6 gene significantly reduced vegetative growth and virulence in both M. oryzae and Alternaria alternata. Through high-throughput screening, we identified a small-molecule compound, Pan-RAS-IN-1, which targets MoCox6 to inhibit mitophagy, thereby suppressing M. oryzae virulence. Pan-RAS-IN-1 exhibits broad-spectrum antifungal activity, and its application to rice plants significantly suppressed rice blast incidence.

Indexed as

AscomycotaElectron Transport Complex IVFungal ProteinsMagnaportheMitophagyAlternariaAntifungal AgentsGene DeletionMitochondriaMitochondrial MembranesOryzaPlant DiseasesVirulenceAntifungal AgentsElectron Transport Complex IVFungal Proteins

Identifiers

PMID42009759
PMCPMC13523041

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.