Evidence map›Paper›PMID 42009893›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Characteristics and outcomes of preterm infants with pulmonary vein stenosis in the contemporary era: a PHIS database analysis.

Mohamed F Elsisy, Fred Z Lam, Mark M Naguib, Mary E Dees, James C Gay, George T Nicholson

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Mohamed F ElsisyThomas P. Graham, Jr., Division of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA. mohamed.elsisy@vumc.org.ORCID http://orcid.org/0000-0002-8184-9203
Fred Z LamThomas P. Graham, Jr., Division of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
Mark M NaguibThomas P. Graham, Jr., Division of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
Mary E DeesThomas P. Graham, Jr., Division of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
James C GayDivision of General Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
George T NicholsonThomas P. Graham, Jr., Division of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulmonary vein stenosis (PVS) is increasingly recognized in preterm infants, yet data regarding characteristics and outcomes remain limited.

methodsA review of hospitalizations from 50 children's hospitals across the United States participating in the Pediatric Health Information System (PHIS) database was performed. We identified 268,461 pediatric patients (≤24 months of age) with a history of prematurity (<37 weeks' gestation) admitted between 2016 and 2024. PVS was identified in 703 (0.3%) using ICD-10 diagnosis code I28.8.

resultsBronchopulmonary dysplasia, birthweight ≤1.5 kg, Oxygen and ventilator dependency at discharge, pulmonary hypertension, left-to-right shunt lesions, and necrotizing enterocolitis were associated with PVS. Interestingly, gestational age <28 weeks was not associated with PVS. Patients with PVS had higher in-hospital mortality (11.4% vs 2%, p < 0.01), longer hospitalization, and substantially higher adjusted hospitalization costs. After adjusting for prematurity and comorbidities, PVS remained associated with in-hospital mortality (OR 4.3, 95% CI 3.4-5.5, p < 0.01).

conclusionPVS in preterm infants is associated with in-hospital mortality, morbidity, and resource utilization, highlighting the need for improved recognition and structured surveillance.

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