Evidence map›Paper›PMID 42009907›Full record

ArticleScientific reports2026

Copper isotope fractionation and copper-to-zinc ratios reveal altered metal homeostasis in prostate cancer.

Robert J Raad, Shun-Chung Yang, Justin L Wang, Jeremy J Rosenbaum, Jorge Nieva, Anand Kolatkar, Stephanie N Shishido, William M Berelson, A Joshua West, Peter Kuhn and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Robert J RaadKeck School of Medicine, University of Southern California, Los Angeles, CA, USA. rraad56@gmail.com.
Shun-Chung YangDepartment of Earth Sciences, University of Southern California, Los Angeles, CA, USA.
Justin L WangKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jeremy J RosenbaumKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jorge NievaDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Anand KolatkarMichelson Center for Convergent Bioscience, Convergent Science Institute in Cancer, University of Southern California, Los Angeles, CA, USA.
Stephanie N ShishidoMichelson Center for Convergent Bioscience, Convergent Science Institute in Cancer, University of Southern California, Los Angeles, CA, USA.
William M BerelsonDepartment of Earth Sciences, University of Southern California, Los Angeles, CA, USA.
A Joshua WestDepartment of Earth Sciences, University of Southern California, Los Angeles, CA, USA.
Peter KuhnMichelson Center for Convergent Bioscience, Convergent Science Institute in Cancer, University of Southern California, Los Angeles, CA, USA.
Seth G JohnDepartment of Earth Sciences, University of Southern California, Los Angeles, CA, USA.

Funding

USC Norris Comprehensive Cancer Center (CORE) Support P30CA014089
6 · The paper itself

Abstract

Trace metal homeostasis is increasingly recognized as a reflection of cellular metabolism and redox balance. This study applies high-precision copper isotope and elemental ratio analysis to human serum to investigate how prostate cancer alters systemic metal regulation. Using multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) adapted from geochemical applications, we quantified copper isotope fractionation and Cu/Zn ratios across disease stages. Patients with localized or newly metastatic prostate cancer exhibited isotopically heavier serum copper compared to healthy controls, while advanced, castration-resistant disease showed higher copper concentrations, lower zinc levels, and elevated Cu/Zn ratios. Together, these findings suggest that prostate cancer-associated alterations in copper and zinc homeostasis may reflect modulation by sex steroid-dependent physiological states. They also demonstrate the sensitivity of MC-ICP-MS in detecting subtle isotopic shifts in biological samples and establish its value as a tool for characterizing metabolic and redox alterations in prostate cancer.

Indexed as

CopperHomeostasisProstatic NeoplasmsZincHumansIsotopesMaleMass SpectrometryCopperIsotopesZincCastration-resistant prostate cancerMetallomicsMulti-collector inductively coupled plasma mass spectrometryStable isotope analysisTrace metal metabolism

Identifiers

PMID42009907
PMCPMC13261131

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.