Evidence map›Paper›PMID 42009986›Full record

ArticleNeurochemical research2026

Unpredictable Chronic Mild Stress Upregulates Dopamine Receptor Expression Independent of Fatty Acid-Binding Protein 7 Gene Deletion.

Huy Lu, Nicole Roeder, Brittany Richardson, John Hamilton, George Lagamjis, Yuji Owada, Yoshiteru Kagawa, Abhisheak Sharma, Panayotis K Thanos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huy LuBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1021 Main Street, 14203-1016, Buffalo, NY, 14068, USA.
Nicole RoederBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1021 Main Street, 14203-1016, Buffalo, NY, 14068, USA.
Brittany RichardsonBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1021 Main Street, 14203-1016, Buffalo, NY, 14068, USA.
John HamiltonBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1021 Main Street, 14203-1016, Buffalo, NY, 14068, USA.
George LagamjisBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1021 Main Street, 14203-1016, Buffalo, NY, 14068, USA.
Yuji OwadaDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, Seiryo-cho 2-1, Aobaku, Sendai, 980-8575, Japan.
Yoshiteru KagawaDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, Seiryo-cho 2-1, Aobaku, Sendai, 980-8575, Japan.
Abhisheak SharmaDepartment of Pharmaceutics, University of Florida, Gainesville, FL, 32610, USA.
Panayotis K ThanosBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1021 Main Street, 14203-1016, Buffalo, NY, 14068, USA. thanos@buffalo.edu.

Funding

Anandamide Transport InhibitorsR01DA035923 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI KACZOCHA, MARTIN · 2013 to 2017
$3.8M
FABPs: Novel Roles in Pain and InflammationR01DA035949 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI KACZOCHA, MARTIN · 2014 to 2022
$3.0M
NIDA NIH HHS R01 DA035923NIDA NIH HHS R01 DA035949Research Foundation for the State University of New York, United States RIAQ0940University at Buffalo ELN
6 · The paper itself

Abstract

Fatty acid-binding protein 7 (FABP7) assists in the intracellular trafficking of endogenous cannabinoids and polyunsaturated fatty acids (PUFAs) and has been implicated for various psychiatric diseases. Rising evidence demonstrates the crosstalk between the endocannabinoid and dopaminergic systems, particularly in response to stress. The present study seeks to examine the role of FABP7 expression under chronic stress conditions and its impact on the dopaminergic system, specifically dopamine D1 receptor (D1R) and dopamine D2 receptor (D2R) levels. Adult male FABP7

Indexed as

Fatty Acid-Binding Protein 7Gene DeletionReceptors, Dopamine D1Receptors, Dopamine D2Stress, PsychologicalUp-RegulationAnimalsChronic DiseaseMaleMiceMice, Inbred C57BLMice, KnockoutFabp7 protein, mouseFatty Acid-Binding Protein 7Receptors, Dopamine D1Receptors, Dopamine D2D1 receptorsD2 receptorsDopamineEndocannabinoidFatty acid-binding protein 7Unpredictable chronic mild stress

Identifiers

PMID42009986
PMCPMC13095973

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.