Observational studyBMC cardiovascular disorders2026
Assessment of left ventricular global longitudinal strain and echocardiographic changes before and after PCI in Vietnamese patients with stable angina - a single center study.
Observational study in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCoronary artery disease (CAD) is a leading cause of death in Vietnam. Global longitudinal strain (LVGLS) is a non-invasive tool for early CAD detection and post-revascularization assessment. This study aimed to measure LVGLS in stable angina patients and assess changes after percutaneous coronary intervention (PCI).
methodsWe conducted a prospective observational study at Kien Giang General Hospital from 5/2021 to 6/2022, enrolling patients ≥ 18 years with stable angina scheduled for elective PCI. Demographic data, lab results, and comorbidities were collected via medical records and interviews. Two-dimensional speckle-tracking echocardiography was performed before coronary angiography and 3 months post-PCI. LVGLS was categorized as normal or abnormal (threshold: 16%). A paired t-test was used to assess LVGLS changes before and after PCI, with statistical significance set at p < 0.05.
resultsThe study included 60 patients with a mean age of 66.9 ± 9.0 years (1:1 male-to-female). The average LVGLS was 15.1 ± 3.1%. Patients with abnormal LVGLS had a higher percentage of triple vessel disease (40.6% vs. 14.3%, p = 0.05), more CCS class III-IV angina (65.7% vs. 39.3%, p = 0.04), higher resting heart rates (83.2 ± 12.0 bpm vs. 73.1 ± 13.2 bpm, p < 0.05), lower LVEF (49.9 ± 7.2% vs. 56.7 ± 5.7%, p < 0.05), and more frequent wall motion abnormalities (81.3% vs. 53.6%, p = 0.02) compared to those with normal LVGLS. Of the 60 patients, 55 (91.7%) underwent PCI. At three months post-PCI, average LVGLS improved significantly, from 15.0 ± 3.3% to 16.1 ± 2.3% (mean difference 1.1, 95% CI: 0.6–1.6, p < 0.05). LVGLS improvement was consistent across subgroups, regardless of vessel disease, coronary artery territories, or baseline LVEF (except for those with low LVEF), without a corresponding increase in LVEF during the same period.
conclusionOur findings suggest that LVGLS may serve as a complementary marker of early myocardial recovery that could contribute to comprehensive risk assessment post-PCI. Larger studies with extended follow-up are needed to validate these results and evaluate the long-term prognostic value of LVGLS post-PCI.
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