Evidence map›Paper›PMID 42010697›Full record

ArticleTrials2026

EMERGE Mothers and Kids: a longitudinal cohort study of mothers and children enrolled in the randomized placebo-controlled trial of metformin in women with GDM (EMERGE): study protocol.

Roberta Scairati, Christine Newman, Alberto Alvarez-Iglesias, Andrew Smyth, Paula M O'Shea, Declan Devane, Paddy Gillespie, Aoife M Egan, Martin O'Donnell, Fidelma P Dunne

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06327191 (EMERGE Mothers and Kids), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06327191 completednot on this map

EMERGE Mothers and Kids: a Longitudinal Cohort Study of Mothers and Kids Enrolled in the Randomized Placebo Controlled Trial of Metformin in Women With GDM (EMERGE)

TypeobservationalSponsorNational University of Ireland, Galway, IrelandRan2024 to 2026Enrolled370ConditionsGestational DiabetesArmsNo intervention as the study is observational.
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roberta ScairatiHRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland.
Christine NewmanHRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie.
Alberto Alvarez-IglesiasHRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland.
Andrew SmythHRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland.
Paula M O'SheaCollege of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland.
Declan DevaneHRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland.
Paddy GillespieSchool of Business and Economics, University of Galway, Galway City, Co Galway, Ireland.
Aoife M EganMayo Clinic, Rochester, MN, USA.
Martin O'DonnellHRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland.
Fidelma P DunneHRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPregnancies complicated by gestational diabetes mellitus (GDM) are associated with increased risks of adverse perinatal outcomes and with long-term metabolic and cardiovascular consequences for both mother and child. The original EMERGE randomized controlled trial (RCT) evaluated the effectiveness of early metformin in addition to usual care in women with GDM on glycemic control and perinatal outcomes. The primary objective of the EMERGE Mothers and Kids study is to evaluate long-term maternal cardiometabolic health and child anthropometric and neurodevelopmental outcomes following participation in the EMERGE trial.

methodsThis is a prospective, observational longitudinal cohort follow-up study of women and their children previously enrolled in the EMERGE trial (NCT06327191). Participants are invited to attend a follow-up visit in a single-site hospital-based clinical research setting at the Clinical Research Facility Galway, Ireland. Key inclusion criteria are women and their children who participated in the EMERGE trial and consent to follow-up. Key exclusion criteria include participants who did not provide consent for future follow-up studies. The planned follow-up sample is a pragmatic convenience sample of up to 321 mother-child pairs. A single follow-up visit will be conducted up to 6 years after the index pregnancy. Maternal assessments include anthropometric data, glucose tolerance, and metabolic parameters. Child assessments include growth metrics, adiposity measured via skinfold thickness, and neurodevelopmental status assessed through validated questionnaires. Additional data on quality of life, mental health, breastfeeding, and health economics will also be collected. DISCUSSION: This study aims to provide insights into the long-term safety and efficacy of metformin use during pregnancy, addressing the evidence gap in maternal cardiometabolic outcomes after metformin-treated GDM while also assessing child anthropometric and neurodevelopmental outcomes.

trial registrationClinicalTrials.gov NCT06327191. Registered on November 21, 2023. First planned enrollment in this follow-up study: July 2024. Trial record available at https://clinicaltrials.gov/study/NCT06327191 .

Indexed as

Diabetes, GestationalHypoglycemic AgentsMetforminAdultBlood GlucoseChildChild DevelopmentChild, PreschoolFemaleHumansInfantInfant, NewbornLongitudinal StudiesObservational Studies as TopicPregnancyProspective StudiesBlood GlucoseHypoglycemic AgentsMetforminGestational diabetes mellitusLong-term follow-upMetforminPregnancyRandomized controlled trial

Identifiers

PMID42010697
PMCPMC13224567

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.