SynthesisActa paediatrica (Oslo, Norway : 1992)2026
Nicotine Exposure During Pregnancy and Postnatal Cognitive Outcomes: A Systematic Review and Meta-Analysis.
Synthesis in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
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Abstract
aimNicotine exposure during pregnancy interferes with critical periods of foetal brain development, disrupting the timing and functioning of neurodevelopment. This systematic review and meta-analysis aims to evaluate the effect of prenatal nicotine exposure on postnatal cognitive outcomes.
methodsWeb of Science, PubMed, PsycINFOand OpenGrey databases were searched, with no date restrictions. Human (k = 1) and animal research (k = 8) was included. Studies were required to include at least one postnatal cognitive measure during the pre-weaning period.
resultsExposure to nicotine during pregnancy negatively impacted postnatal outcomes of spatial memory (Cohen's d = -1.117; 95% CI [-2.112, -0.123]), centre exploration in animal studies (d = -1.054; 95% CI [-1.659, -0.449]), and reflex development in human and animal studies (d = -1.126; 95% CI [-1.737, -0.514]). Prenatal nicotine exposure did not have a significant effect on ambulation (d = -0.044; 95% CI [0.485, 0.397]) and rearing (d = -0.45; 95% CI [-1.042, 0.142]) in animals.
conclusionFindings suggest that certain domains may be especially vulnerable to prenatal nicotine exposure, with reflex development showing the strongest effect. The scarcity of human studies underscores an urgent need for further research to ensure informed recommendations on nicotine intake during pregnancy.
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