ArticleDose-response : a publication of International Hormesis Society
Characterization of the Intestinal Metabolic Profiles Following Photon FLASH Irradiation.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dosimetric Characterization and Workflow Optimization of the FLASH-SARRP for Reliable Preclinical Radiobiological Studies.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Ultra-high dose rate radiotherapy, commonly referred to as FLASH radiotherapy, is a transformative focus in radiotherapeutic research. This study aimed to identify intestinal contents based metabolic biomarkers of photon FLASH. Methods: C57BL/6J mice were exposed to 0 Gy, 10 Gy, 12 Gy, or 14 Gy of photon FLASH irradiation (FLASH-IR) without a conventional irradiation. The intestinal contents were collected 3.5 d post-iiradiation, and subjected to liquid chromatography-mass spectrometry. Results: Metabolomic profiling revealed 25 differential metabolites that were consistently differentially regulated across the comparisons of 10 Gy vs. 0 Gy, 12 Gy vs. 0 Gy, and 14 Gy vs. 0 Gy groups. Notably, a dose-dependent positive correlation was observed for 3-hydroxyanthranilate, while 13 metabolites-including guanosine, adenosine monophosphate, and hydroquinone-exhibited a significant negative correlation with increasing FLASH-IR dose. Further enrichment analysis identified several perturbed metabolic cascades, prominently involving the PI3K-AKT signaling pathway, tyrosine metabolism, and purine metabolism. Conclusions: These findings illuminated the intestinal metabolic signatures post photon FLASH-IR, offering insights to optimize FLASH radiotherapy parameters and enhance its therapeutic ratio.
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