Evidence map›Paper›PMID 42011727›Full record

ArticleAnnals of clinical and translational neurology2026

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS.

Wendy Qi, Katharine Lee, Kerry C Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M Baumer

Abstract read
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In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Wendy QiDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.ORCID https://orcid.org/0000-0002-1442-1733
Katharine LeeDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
Kerry C NixDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
Miguel MenchacaDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
Xiwei ShéDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.ORCID https://orcid.org/0000-0002-6446-2031
Lorelei Santa MariaDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
Wei WuDepartment of Psychiatry & Behavioral Sciences, Stanford University, Palo Alto, California, USA.
Zihuai HeDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
Fiona M BaumerDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.ORCID https://orcid.org/0000-0002-9162-9458

Funding

Speaking of Spikes: Connectivity and Language in Benign Epilepsy with Centrotemporal SpikesK23NS116110 · NINDS · STANFORD UNIVERSITY · PI BAUMER, FIONA MITCHELL · 2020 to 2024
$1.1M
NINDS NIH HHS K23 NS116110Principe & O'Farrell familyStanford Maternal and Child Health Research InstituteThe Doris Duke Foundation and The Rita Allen FoundationWu Tsai Neurosciences Institute, Stanford University
6 · The paper itself

Abstract

objectiveSelf-Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross-network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.

methodsWe recorded high-density EEG from right-handed children with SeLECTS (n = 31) and age-matched controls (n = 32) during verb generation, repetition, and resting tasks. Phonological awareness was assessed using the Comprehensive Test of Phonological Processing-2. Connectivity between bilateral motor cortices and language regions (the left inferior frontal and superior temporal cortices and their right hemisphere homologs) was measured using the weighted Phase Lag Index (wPLI).

resultsChildren with SeLECTS demonstrated significantly elevated connectivity between motor and language regions during language processing. Motor-to-frontal connectivity was higher in SeLECTS during both verb generation and repetition tasks. Frontal-to-temporal connectivity was elevated specifically during verb generation. Exploratory analyses suggest high interhemispheric connectivity (between the left and right hemispheres) during language tasks is associated with poor phonological awareness in children with SeLECTS, but not controls. Together, we found that children with SeLECTS exhibited pathologically elevated connectivity between motor and language networks that was strongly associated with impaired phonological awareness.

interpretationThese findings establish task-specific connectivity abnormalities as a characteristic feature of SeLECTS and suggest interhemispheric connectivity patterns may relate to language outcomes, warranting further investigation as potential targets for therapeutic neuromodulation.

Indexed as

Benign Epilepsy with Centrotemporal Spikes (BECTS)Childhood Epilepsy with Centrotemporal Spikes (CECTS)electroencephalogramfunctional connectivitylanguage processingpediatric epilepsyphonological awarenessRolandic Epilepsy

Identifiers

PMID42011727
PMCPMC13394123

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.