ArticlePest management science2026
COF-PEI-PEG nanocarriers enhance dsRNA delivery to improve RNAi-based insect pest control.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundFoliar application of RNA interference (RNAi)-based products offers a promising strategy for protecting crops against insect pests. This approach involves the direct spraying of exogenous double-stranded RNA (dsRNA) to silence specific target genes in pests. However, its practical efficacy is constrained by the environmental degradation of the dsRNA, rapid degradation by gut nucleases, inefficient cellular internalization and limited endosomal escape. The integration of nanotechnology with RNAi has emerged as a promising frontier in sustainable pest control, offering improved dsRNA stability, enhanced cellular delivery, and the potential to reduce conventional pesticide use. In this study, we explored the use of a positively charged covalent organic framework (COF)-based nanocarrier functionalized with polyethylenimine (PEI) and polyethylene glycol (PEG) for dsRNA delivery.
resultsThe resulting COF-PEI-PEG@dsRNA complexes effectively resisted degradation by nuclease-rich midgut extracts. Moreover, COF-PEI-PEG facilitated efficient dsRNA delivery into Drosophila S2 and Lepidopteran Sf9 cells, resulting in significant improvement in target gene knockdown. In vivo, COF-PEI-PEG@dsRNA significantly enhanced RNAi efficacy in Leptinotarsa decemlineata and Drosophila suzukii, although no improvement was observed in Spodoptera exigua.
conclusionCollectively, our findings highlight the potential of COF-PEI-PEG as effective dsRNA delivery platforms, offering a novel and versatile tool to enhance RNAi-based insect management and fundamental entomological research. © 2026 Society of Chemical Industry.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.