Evidence map›Paper›PMID 42011959›Full record

ArticleJournal of neurophysiology2026

Dopaminergic modulation of low- and high-spontaneous rate type I auditory nerve fiber activity.

Daniel O J Reijntjes, Marco Manca, Jingjing Sherry Wu, Philippe F Y Vincent, Kushal Sharma, Eunyoung Yi, Grace Tate, Kevin J Psoter, Elisabeth Glowatzki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel O J ReijntjesDepartment of Otolaryngology-Head and Neck Surgery, The Center for Hearing and Balance, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-6485-588X
Marco MancaDepartment of Otolaryngology-Head and Neck Surgery, The Center for Hearing and Balance, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0001-9569-2924
Jingjing Sherry WuDepartment of Neurobiology, Harvard Medical School, Blavatnik Institute, Boston, Massachusetts, United States.ORCID 0000-0001-9625-1661
Philippe F Y VincentDepartment of Otolaryngology-Head and Neck Surgery, The Center for Hearing and Balance, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0001-7712-7198
Kushal SharmaSound Pharmaceuticals, Inc., Seattle, Washington, United States.ORCID 0000-0001-6554-0479
Eunyoung YiCollege of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, Republic of Korea.ORCID 0000-0002-9592-0736
Grace TateDepartment of Otolaryngology-Head and Neck Surgery, The Center for Hearing and Balance, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Kevin J PsoterDepartment of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Elisabeth GlowatzkiDepartment of Otolaryngology-Head and Neck Surgery, The Center for Hearing and Balance, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-3135-658X

Funding

AFFERENT SYNAPTIC TRANSMISSION IN THE MAMMALIAN COCHLEAR01DC006476 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI GLOWATZKI, ELISABETH · 2004 to 2022
$6.4M
HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) RO1 DC006476HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) RO1 DC012957John Mitchell Jr. fundNational Research Foundation of Korea (NRF) NRF 2022R1I1A3072036NIDCD NIH HHS R01 DC006476The David M. Rubenstein Precision Medicine Center of Excellence In Hearing FundThe David M. Rubenstein ProfessorshipThe Geraldine Fox Endowed Research Fund
6 · The paper itself

Abstract

Deflections of inner hair cell (IHC) stereocilia in response to sound trigger glutamate release from cochlear IHCs, which initiates action potential firing in auditory nerve fibers (ANFs) via IHC/ANF synapses. Physiological subgroups of ANFs exist, whereby low-spontaneous rate ANFs (low-SR ANFs) contact IHCs preferentially on the modiolar side, and high-SR ANFs on the pillar side. Efferent lateral olivocochlear (LOC) neurons originating in the brainstem terminate in the cochlea and release neuromodulatory transmitters onto ANF endings close to their contact with IHCs. Of these transmitters, dopamine has been shown to reduce ANF firing rates. Here, it was examined whether dopamine and D1-like and D2-like dopamine receptor agonists affect low- and high-SR fibers differently, by monitoring SRs from bouton endings of posthearing rat-cochlear-coils with extracellular loose-patch recordings. In genetic reporter mouse models, the expression of

Indexed as

Action PotentialsCochlear NerveDopamineHair Cells, Auditory, InnerReceptors, Dopamine D1Receptors, Dopamine D2AnimalsCochleaDopamine AgonistsMaleMiceRatsDopamineDopamine AgonistsDrd1 protein, mouseDRD2 protein, mouseReceptors, Dopamine D1Receptors, Dopamine D2auditory nerve fibercochleadopaminelateral efferentspiral ganglion neuron

Identifiers

PMID42011959
PMCPMC13261627

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.