Evidence mapPaperPMID 42012205Full record

ArticleInorganic chemistry2026

Human Transthyretin with a Tailored Gd(III) Complex as a High-Relaxivity MRI Contrast Agent.

Jlenia Bindi, Adam Kubrak, Yiqing Lei, Megan Kaster, Linda Cerofolini, Enrico Ravera, Thomas J Meade, Marco Fragai, Giacomo Parigi

Abstract read
In one paragraph

Article in Inorganic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jlenia BindiDepartment of Chemistry "Ugo Schiff" and Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino 50019, Italy.
Adam KubrakDepartment of Chemistry "Ugo Schiff" and Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino 50019, Italy.
Yiqing LeiDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.ORCID 0009-0005-6992-2358
Megan KasterDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.ORCID 0000-0001-5550-4028
Linda CerofoliniDepartment of Chemistry "Ugo Schiff" and Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino 50019, Italy.
Enrico RaveraDepartment of Chemistry "Ugo Schiff" and Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino 50019, Italy.ORCID 0000-0001-7708-9208
Thomas J MeadeDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.ORCID 0000-0001-6202-1155
Marco FragaiDepartment of Chemistry "Ugo Schiff" and Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino 50019, Italy.ORCID 0000-0002-8440-1690
Giacomo ParigiDepartment of Chemistry "Ugo Schiff" and Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino 50019, Italy.ORCID 0000-0002-1989-4644

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein-based biomaterials are attractive platforms for medical applications, as they can combine drug delivery, targeting, and diagnostic imaging. In this work, human transthyretin (TTR), a 55 kDa homotetrameric plasma protein with drug-carrier potential, was functionalized with the paramagnetic complex

Indexed as

Contrast MediaCoordination ComplexesGadoliniumMagnetic Resonance ImagingPrealbuminHumansMolecular StructureContrast MediaCoordination ComplexesGadoliniumPrealbuminTTR protein, human

Identifiers

PMID42012205
PMCPMC13147334

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.