Observational studyClinical cardiology2026
Age Differences in Acute Chest Pain Care in a Multisite US Cohort.
Observational study in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThis study aims to determine if differences in age affect safety and healthcare utilization among patients with chest pain in a multisite US ED cohort, after accounting for comorbidities and high-sensitivity troponin (hs-cTn).
methodsWe conducted a multisite observational study using the Wake Forest Chest Pain Registry, which included patients ≥ 18 years old with chest pain across 25 EDs (01/01/2021 to 12/31/2021). Each site used an hs-cTn chest pain protocol. Patients were categorized as older (≥ 65 years), middle-aged (46-64 years), or young (18-45 years). The primary safety outcome was death or MI at 30 days. The primary healthcare utilization outcome was 30-day hospitalization. Multivariable logistic regression models assessed the association between age and outcomes, adjusting for sex, race, ethnicity, obesity, smoking, rurality, coronary disease, diabetes, hypertension, hyperlipidemia, insurance, site, and hs-cTn, with young patients as the reference.
resultsAmong 40 979 patients, 25.1% were older, 39.7% middle-aged, and 35.2% young. At 30 days, death or MI occurred in 7.3% (750/10 298) of older, 3.8% (611/16 260) of middle-aged, and 0.8% (108/14 421) of young patients. After adjustment, death or MI at 30 days was more common among older (aOR 1.57, 95% CI 1.17-2.12) and middle-aged (aOR 1.57, 95% CI 1.22-2.02) patients. Hospitalization at 30 days occurred in 56.3% (5799/10 298) of older, 35.4% (5761/16 260) of middle-aged, and 12.8% (1849/14 421) of young patients. With adjustment, hospitalization remained more common among older (aOR 2.51, 95% CI 2.27-2.78) and middle-aged (aOR 1.93, 95% CI 1.80-2.07) patients.
conclusionAfter adjusting for comorbidities and hs-cTn results, older adults had higher rates of death or MI and hospitalization at 30 days.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.